| EC |
2.1.1.45 |
| Accepted name: |
thymidylate synthase |
| Reaction: |
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP |
|
For diagram of C1 metabolism, click here |
| Other name(s): |
dTMP synthase; thymidylate synthetase; methylenetetrahydrofolate:dUMP C-methyltransferase; TMP synthetase |
| Systematic name: |
5,10-methylenetetrahydrofolate:dUMP C-methyltransferase |
| Links to other databases: |
BRENDA, EXPASY, Gene, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9031-61-2 |
| References: |
| 1. |
Blakley, R.L. The biosynthesis of thymidylic acid. IV. Further studies on thymidylate synthase. J. Biol. Chem. 238 (1963) 2113–2118. |
| 2. |
Lockshin, A., Moran, R.G. and Danenberg, P.V. Thymidylate synthetase purified to homogeneity from human leukemic cells. Proc. Natl. Acad. Sci. USA 76 (1979) 750–754. [DOI] [PMID: 34155] |
| 3. |
Slavik, K. and Slavikova, V. Purification of thymidylate synthetase from enzyme-poor sources by affinity chromatography. Methods Enzymol. 66 (1980) 709–723. [PMID: 6990200] |
| 4. |
Wahba, A.J. and Friedkin, M. The enzymatic synthesis of thymidylate. I. Early steps in the purification of thymidylate synthetase of Escherichia coli. J. Biol. Chem. 237 (1962) 3794–3801. [PMID: 13998281] |
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| [EC 2.1.1.45 created 1976] |
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