| EC |
2.1.1.6 |
| Accepted name: |
catechol O-methyltransferase |
| Reaction: |
S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol |
| Other name(s): |
COMT I ; COMT II; S-COMT (soluble form of catechol-O-methyltransferase); MB-COMT (membrane-bound form of catechol-O-methyltransferase); catechol methyltransferase; catecholamine O-methyltransferase |
| Systematic name: |
S-adenosyl-L-methionine:catechol O-methyltransferase |
| Comments: |
The mammalian enzyme acts more rapidly on catecholamines such as adrenaline or noradrenaline than on catechols. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9012-25-3 |
| References: |
| 1. |
Axelrod, J. and Tomchick, R. Enzymatic O-methylation of epinephrine and other catechols. J. Biol. Chem. 233 (1958) 702–705. [PMID: 13575440] |
| 2. |
Gulliver, P.A. and Tipton, K.F. The purification and properties of pig brain catechol-O-methyltransferase. J. Neurochem. 32 (1979) 1525–1529. [DOI] [PMID: 438821] |
| 3. |
Huh, M.M.O. and Friedhof, A.J. Multiple molecular forms of catechol-O-methyltransferase. Evidence for two distinct forms, and their purification and physical characterization. J. Biol. Chem. 254 (1979) 299–308. [PMID: 762061] |
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| [EC 2.1.1.6 created 1965] |
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