ExplorEnz: EC 2.1.1.62

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2.1.1.62

Accepted name:

mRNA (2′-O-methyladenosine-N⁶-)-methyltransferase

Reaction:

S-adenosyl-L-methionine + a 5-(N⁷-methyl 5-triphosphoguanosine)-2′-O-methyladenosine-[mRNA] = S-adenosyl-L-homocysteine + a 5-(N⁷-methyl 5-triphosphoguanosine)-N⁶,2′-O-dimethyladenosine-[mRNA]

Glossary:

a 5-(N⁷-methyl 5-triphosphoguanosine)-2′-O-methyladenosine-[mRNA] = m7G(5′)pppAm-[mRNA]
a 5-(N⁷-methyl 5-triphosphoguanosine)-N⁶,2′-O-dimethyladenosine-[mRNA] = m7G(5′)pppm⁶Am-[mRNA]

Other name(s):

messenger ribonucleate 2′-O-methyladenosine N^G-methyltransferase; S-adenosyl-L-methionine:mRNA (2′-O-methyladenosine-6-N-)-methyltransferase

Systematic name:

S-adenosyl-L-methionine:mRNA (2′-O-methyladenosine-N⁶-)-methyltransferase

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 68009-87-0

References:

1.	Keith, J.M., Ensinger, M.J. and Moss, B. HeLa cell RNA (2′-O-methyladenosine-N⁶-)-methyltransferase specific for the capped 5′-end of messenger RNA. J. Biol. Chem. 253 (1978) 5033–5039. [PMID: 670176]
2.	Mauer, J., Luo, X., Blanjoie, A., Jiao, X., Grozhik, A.V., Patil, D.P., Linder, B., Pickering, B.F., Vasseur, J.J., Chen, Q., Gross, S.S., Elemento, O., Debart, F., Kiledjian, M. and Jaffrey, S.R. Reversible methylation of m⁶Am in the 5′ cap controls mRNA stability. Nature 541 (2017) 371–375. [DOI] [PMID: 28002401]

[EC 2.1.1.62 created 1982]