| EC |
2.1.1.72 |
| Accepted name: |
site-specific DNA-methyltransferase (adenine-specific) |
| Reaction: |
S-adenosyl-L-methionine + adenine in DNA = S-adenosyl-L-homocysteine + N6-methyladenine in DNA |
| Other name(s): |
modification methylase; restriction-modification system |
| Systematic name: |
S-adenosyl-L-methionine:adenine in DNA N6-methyltransferase |
| Comments: |
This is a large group of enzymes, most of which form so-called ’restriction-modification systems’ with nucleases that possess similar site specificity [the nucleases are listed as either EC 3.1.21.3 (type 1 site-specific deoxyribonuclease), EC 3.1.21.4 (type II site-specific deoxyribonuclease) or EC 3.1.21.5 (type III site-specific deoxyribonuclease)]. A complete listing of all of these enzymes has been produced by R.J. Roberts and is available on-line at http://rebase.neb.com/rebase/rebase.html. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 69553-52-2 |
| References: |
| 1. |
Kessler, C. and Manta, V. Specificity of restriction endonucleases and DNA modification methyltransferases: a review. Gene 92 (1990) 1–248. [DOI] [PMID: 2172084] |
| 2. |
Roberts, R.J. Restriction enzymes and their isoschizomers. Nucleic Acids Res. 18 (1990) 2331–2365. [PMID: 2159140] |
| 3. |
Yuan, R. Structure and mechanism of multifunctional restriction endonucleases. Annu. Rev. Biochem. 50 (1981) 285–319. [DOI] [PMID: 6267988] |
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| [EC 2.1.1.72 created 1984] |
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