The Enzyme Database

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Accepted name: cyclopropane-fatty-acyl-phospholipid synthase
Reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
Other name(s): cyclopropane synthetase; unsaturated-phospholipid methyltransferase; cyclopropane synthase; cyclopropane fatty acid synthase; cyclopropane fatty acid synthetase; CFA synthase
Systematic name: S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (cyclizing)
Comments: The enzyme adds a methylene group across the 9,10 position of a Δ9-olefinic acyl chain in phosphatidylethanolamine or, more slowly, phosphatidylglycerol or phosphatidylinositol, forming a cyclopropane derivative (cf. EC methylene-fatty-acyl-phospholipid synthase).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 51845-48-8
1.  Chung, A.E. and Law, J.H. Cyclopropane fatty acid synthetase: Partial purification and properties. Biochemistry 3 (1964) 967–974. [PMID: 14214089]
2.  Zalkin, H., Law, J.H. and Goldfine, H. Enzymatic synthesis of cyclopropane fatty acids catalyzed by bacterial extracts. J. Biol. Chem. 238 (1963) 1242–1248. [PMID: 14003136]
[EC created 1986]

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