The Enzyme Database

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Accepted name: 3-methylquercetin 7-O-methyltransferase
Reaction: S-adenosyl-L-methionine + 5,7,3′,4′-tetrahydroxy-3-methoxyflavone = S-adenosyl-L-homocysteine + 5,3′,4′-trihydroxy-3,7-dimethoxyflavone
For diagram of the biosynthesis of methylated quercetin derivatives, click here
Other name(s): flavonol 7-O-methyltransferase; flavonol 7-methyltransferase; 7-OMT; S-adenosyl-L-methionine:3′,4′,5,7-tetrahydroxy-3-methoxyflavone 7-O-methyltransferase; 3-methylquercitin 7-O-methyltransferase [mis-spelt]
Systematic name: S-adenosyl-L-methionine:5,7,3′,4′-tetrahydroxy-3-methoxyflavone 7-O-methyltransferase
Comments: Involved with EC quercetin 3-O-methyltransferase and EC 3,7-dimethylquercetin 4′-O-methyltransferase in the methylation of quercetin to 3,7,4′-trimethylquercetin in Chrysosplenium americanum. Does not act on flavones, dihydroflavonols, or their glucosides.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 97089-67-3
1.  De Luca, V. and Ibrahim, R.K. Enzymatic synthesis of polymethylated flavonols in Chrysosplenium americanum. I. Partial purification and some properties of S-adenosyl-L-methionine:flavonol 3-, 6-, 7-, and 4′-O-methyltransferases. Arch. Biochem. Biophys. 238 (1985) 596–605. [DOI] [PMID: 3994393]
[EC created 1989]

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