| EC |
2.1.2.1 |
| Accepted name: |
glycine hydroxymethyltransferase |
| Reaction: |
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine |
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For diagram of folate cofactors, click here and for diagram of C1 metabolism, click here |
| Other name(s): |
serine aldolase; threonine aldolase; serine hydroxymethylase; serine hydroxymethyltransferase; allothreonine aldolase; L-serine hydroxymethyltransferase; L-threonine aldolase; serine transhydroxymethylase |
| Systematic name: |
5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase |
| Comments: |
A pyridoxal-phosphate protein. Also catalyses the reaction of glycine with acetaldehyde to form L-threonine, and with 4-trimethylammoniobutanal to form 3-hydroxy-N6,N6,N6-trimethyl-L-lysine. |
| Links to other databases: |
BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9029-83-8 |
| References: |
| 1. |
Akhtar, M. and El-Obeid, H.A. Inactivation of serine transhydroxymethylase and threonine aldolase activities. Biochim. Biophys. Acta 258 (1972) 791–799. [DOI] [PMID: 5017703] |
| 2. |
Blakley, R.L. A spectrophotometric study of the reaction catalysed by serine transhydroxymethylase. Biochem. J. 77 (1960) 459–465. [PMID: 16748851] |
| 3. |
Fujioka, M. Purification and properties of serine hydroxymethylase from soluble and mitochondrial fractions of rabbit liver. Biochim. Biophys. Acta 185 (1969) 338–349. [DOI] [PMID: 5808700] |
| 4. |
Kumagai, H., Nagate, T., Yoshida, H. and Yamada, H. Threonine aldolase from Candida humicola. II. Purification, crystallization and properties. Biochim. Biophys. Acta 258 (1972) 779–790. [DOI] [PMID: 5017702] |
| 5. |
Schirch, L.V. and Gross, T. Serine transhydroxymethylase. Identification as the threonine and allothreonine aldolases. J. Biol. Chem. 243 (1968) 5651–5655. [PMID: 5699057] |
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| [EC 2.1.2.1 created 1961, modified 1983] |
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