| EC |
2.1.2.11 |
| Accepted name: |
3-methyl-2-oxobutanoate hydroxymethyltransferase |
| Reaction: |
5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = tetrahydrofolate + 2-dehydropantoate |
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For diagram of the early stages of CoA biosynthesis, click here |
| Other name(s): |
α-ketoisovalerate hydroxymethyltransferase; dehydropantoate hydroxymethyltransferase; ketopantoate hydroxymethyltransferase; oxopantoate hydroxymethyltransferase; 5,10-methylene tetrahydrofolate:α-ketoisovalerate hydroxymethyltransferase |
| Systematic name: |
5,10-methylenetetrahydrofolate:3-methyl-2-oxobutanoate hydroxymethyltransferase |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 56093-17-5 |
| References: |
| 1. |
Powers, S.G. and Snell, E.E. Ketopantoate hydroxymethyltransferase. II. Physical, catalytic, and regulatory properties. J. Biol. Chem. 251 (1976) 3786–3793. [PMID: 6463] |
| 2. |
Teller, J.H., Powers, S.G. and Snell, E.E. Ketopantoate hydroxymethyltransferase. I. Purification and role in pantothenate biosynthesis. J. Biol. Chem. 251 (1976) 3780–3785. [PMID: 776976] |
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| [EC 2.1.2.11 created 1982] |
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