ExplorEnz: EC 2.1.2.14

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2.1.2.14

Accepted name:

GDP-perosamine N-formyltransferase

Reaction:

10-formyltetrahydrofolate + GDP-α-D-perosamine = tetrahydrofolate + GDP-N-formyl-α-D-perosamine

Glossary:

GDP-α-D-perosamine = GDP-4-amino-4,6-dideoxy-α-D-mannose

Other name(s):

wbkC (gene name)

Systematic name:

10-formyltetrahydrofolate:GDP-α-D-perosamine N-formyltransferase

Comments:

The enzyme, characterized from the bacterium Brucella melitensis, synthesizes a building block of the O antigen produced by Brucella species.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Godfroid, F., Cloeckaert, A., Taminiau, B., Danese, I., Tibor, A., de Bolle, X., Mertens, P. and Letesson, J.J. Genetic organisation of the lipopolysaccharide O-antigen biosynthesis region of Brucella melitensis 16M (wbk). Res. Microbiol. 151 (2000) 655–668. [DOI] [PMID: 11081580]
2.	Riegert, A.S., Chantigian, D.P., Thoden, J.B., Tipton, P.A. and Holden, H.M. Biochemical characterization of WbkC, an N-formyltransferase from Brucella melitensis. Biochemistry 56 (2017) 3657–3668. [DOI] [PMID: 28636341]

[EC 2.1.2.14 created 2021]