ExplorEnz: EC 2.1.3.9

Your query returned 1 entry. Printable version

2.1.3.9

Accepted name:

N-acetylornithine carbamoyltransferase

Reaction:

carbamoyl phosphate + N²-acetyl-L-ornithine = phosphate + N-acetyl-L-citrulline

Glossary:

N-acetyl-L-citrulline = N⁵-acetylcarbamoyl-L-ornithine

Other name(s):

acetylornithine transcarbamylase; N-acetylornithine transcarbamylase; AOTC; carbamoyl-phosphate:2-N-acetyl-L-ornithine carbamoyltransferase; AOTCase

Systematic name:

carbamoyl-phosphate:N²-acetyl-L-ornithine carbamoyltransferase

Comments:

Differs from EC 2.1.3.3, ornithine carbamoyltransferase. This enzyme replaces EC 2.1.3.3 in the canonic arginine biosynthetic pathway of several Eubacteria and has no catalytic activity with L-ornithine as substrate.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 890853-54-0

References:

1.	Shi, D., Morizono, H., Yu, X., Roth, L., Caldovic, L., Allewell, N.M., Malamy, M.H. and Tuchman, M. Crystal structure of N-acetylornithine transcarbamylase from Xanthomonas campestris: a novel enzyme in a new arginine biosynthetic pathway found in several Eubacteria. J. Biol. Chem. 280 (2005) 14366–14369. [DOI] [PMID: 15731101]
2.	Morizono, H., Cabrera-Luque, J., Shi, D., Gallegos, R., Yamaguchi, S., Yu, X., Allewell, N.M., Malamy, M.H. and Tuchman, M. Acetylornithine transcarbamylase: a novel enzyme in arginine biosynthesis. J. Bacteriol. 188 (2006) 2974–2982. [DOI] [PMID: 16585758]

[EC 2.1.3.9 created 2005]