| EC |
2.2.1.7 |
| Accepted name: |
1-deoxy-D-xylulose-5-phosphate synthase |
| Reaction: |
pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2 |
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For diagram of non-mevalonate terpenoid biosynthesis, click here and for mechanism of reaction, click here |
| Glossary: |
thiamine diphosphate = 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-diphosphoethyl)-4-methyl-1,3-thiazolium |
| Other name(s): |
1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating); DXP-synthase |
| Systematic name: |
pyruvate:D-glyceraldehyde-3-phosphate acetaldehydetransferase (decarboxylating) |
| Comments: |
Requires thiamine diphosphate. The enzyme forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, click here). |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 202218-79-9 |
| References: |
| 1. |
Sprenger, G.A., Schörken, U., Weigert, T., Grolle, S., deGraaf, A.A., Taylor, S.V., Begley, T.P., Bringer-Meyer, S. and Sahm, H. Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol. Proc. Natl. Acad. Sci. USA 94 (1997) 12857–12862. [DOI] [PMID: 9371765] |
| 2. |
Kuzuyama, T., Takagi, M., Takahashi, S. and Seto, H. Cloning and characterization of 1-deoxy-D-xylulose 5-phosphate synthase from Streptomyces sp. strain CL190, which uses both the mevalonate and nonmevalonate pathways for isopentenyl diphosphate biosynthesis. J. Bacteriol. 182 (2000) 891–897. [DOI] [PMID: 10648511] |
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| [EC 2.2.1.7 created 2001 as EC 4.1.3.37 transferred 2002 to EC 2.2.1.7] |
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