| EC |
2.3.1.150 |
| Accepted name: |
salutaridinol 7-O-acetyltransferase |
| Reaction: |
acetyl-CoA + salutaridinol = CoA + 7-O-acetylsalutaridinol |
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For diagram of thebaine biosynthesis, click here |
| Systematic name: |
acetyl-CoA:salutaridinol 7-O-acetyltransferase |
| Comments: |
The enzyme is present in the poppy, Papaver somniferum. At pH 8-9 the product, 7-O-acetylsalutaridinol, spontaneously closes the 4→5 oxide bridge by allylic elimination to form the morphine precursor thebaine |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 156859-13-1 |
| References: |
| 1. |
Lenz, R., Zenk, M.H. Closure of the oxide bridge in morphine biosynthesis. Tetrahedron Lett. 35 (1994) 3897–3900. |
| 2. |
Lenz, R., Zenk, M.H. Acetyl-CoA:salutaridinol 7-O-acetyltransferase from Papaver somniferum plant cell cultures. The enzyme catalyzing the formation of thebaine in morphine biosynthesis. J. Biol. Chem. 270 (1995) 31091–31096. [DOI] [PMID: 8537369] |
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| [EC 2.3.1.150 created 1999] |
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