| EC |
2.3.1.162 |
| Accepted name: |
taxadien-5α-ol O-acetyltransferase |
| Reaction: |
acetyl-CoA + taxa-4(20),11-dien-5α-ol = CoA + taxa-4(20),11-dien-5α-yl acetate |
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For diagram of taxadiene biosynthesis, click here |
| Other name(s): |
acetyl coenzyme A:taxa-4(20),11(12)-dien-5α-ol O-acetyl transferase |
| Systematic name: |
acetyl-CoA:taxa-4(20),11-dien-5α-ol O-acetyltransferase |
| Comments: |
This is the third enzyme in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel), which is widely used in the treatment of carcinomas, sarcomas and melanomas. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 229032-29-5 |
| References: |
| 1. |
Walker, K., Ketchum, R.E., Hezari, M., Gatfield, D., Goleniowski, M., Barthol, A. and Croteau, R. Partial purification and characterization of acetyl coenzyme A: taxa-4(20),11(12)-dien-5α-ol O-acetyl transferase that catalyzes the first acylation step of taxol biosynthesis. Arch. Biochem. Biophys. 364 (1999) 273. [DOI] [PMID: 10190984] |
| 2. |
Walker, K., Schoendorf, A. and Croteau, R. Molecular cloning of a taxa-4(20),11(12)-dien-5α-ol-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli. Arch. Biochem. Biophys. 374 (2000) 371–380. [DOI] [PMID: 10666320] |
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| [EC 2.3.1.162 created 2002] |
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