EC |
2.3.1.183 |
Accepted name: |
phosphinothricin acetyltransferase |
Reaction: |
acetyl-CoA + phosphinothricin = CoA + N-acetylphosphinothricin |
Glossary: |
phosphinothricin = glufosinate = 2-amino-4-[hydroxy(methyl)phosphoryl]butanoate |
Other name(s): |
PAT (ambiguous); PPT acetyltransferase; Pt-N-acetyltransferase |
Systematic name: |
acetyl-CoA:phosphinothricin N-acetyltransferase |
Comments: |
The substrate phosphinothricin is used as a nonselective herbicide and is a potent inhibitor of EC 6.3.1.2, glutamine synthetase, a key enzyme of nitrogen metabolism in plants [2]. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
References: |
1. |
Botterman, J., Gosselé, V., Thoen, C. and Lauwereys, M. Characterization of phosphinothricin acetyltransferase and C-terminal enzymatically active fusion proteins. Gene 102 (1991) 33–37. [DOI] [PMID: 1864506] |
2. |
Dröge-Laser, W., Siemeling, U., Pühler, A. and Broer, I. The metabolites of the herbicide L-phosphinothricin (glufosinate) (identification, stability, and mobility in transgenic, herbicide-resistant, and untransformed plants). Plant Physiol. 105 (1994) 159–166. [PMID: 12232195] |
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[EC 2.3.1.183 created 2007] |
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