The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

Accepted name: 4-hydroxycoumarin synthase
Reaction: malonyl-CoA + 2-hydroxybenzoyl-CoA = 2 CoA + 4-hydroxycoumarin + CO2
For diagram of polyketides biosynthesis, click here
Glossary: 2-hydroxybenzoyl-CoA = salicyloyl-CoA
Other name(s): BIS2; BIS3
Systematic name: malonyl-CoA:2-hydroxybenzoyl-CoA malonyltransferase
Comments: The enzyme, a polyketide synthase, can also accept benzoyl-CoA as substrate, which it condenses with 3 malonyl-CoA molecules to form 3,5-dihydroxybiphenyl (cf. EC, biphenyl synthase) [1].
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Liu, B., Raeth, T., Beuerle, T. and Beerhues, L. A novel 4-hydroxycoumarin biosynthetic pathway. Plant Mol. Biol. 72 (2010) 17–25. [DOI] [PMID: 19757094]
[EC created 2012]

Data © 2001–2024 IUBMB
Web site © 2005–2024 Andrew McDonald