Accepted name: curcumin synthase
Reaction: feruloyl-CoA + feruloylacetyl-CoA + H2O = 2 CoA + curcumin + CO2
Glossary: curcumin = (1E,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one
feruloylacetyl-CoA = feruloyl-diketide-CoA
Other name(s): CURS; CURS1 (gene name); CURS2 (gene name); CURS3 (gene name)
Systematic name: feruloyl-CoA:feruloylacetyl-CoA feruloyltransferase (curcumin-forming)
Comments: A polyketide synthase from the plant Curcuma longa (turmeric). Three isoforms exist, CURS1, CURS2 and CURS3. While CURS1 and CURS2 prefer feruloyl-CoA as a starter substrate, CURS3 can accept 4-coumaroyl-CoA equally well [2] (see EC, demethoxycurcumin synthase).
1.  Katsuyama, Y., Kita, T., Funa, N. and Horinouchi, S. Curcuminoid biosynthesis by two type III polyketide synthases in the herb Curcuma longa. J. Biol. Chem. 284 (2009) 11160–11170. [PMID: 19258320]
2.  Katsuyama, Y., Kita, T. and Horinouchi, S. Identification and characterization of multiple curcumin synthases from the herb Curcuma longa. FEBS Lett. 583 (2009) 2799–2803. [PMID: 19622354]
3.  Katsuyama, Y., Miyazono, K., Tanokura, M., Ohnishi, Y. and Horinouchi, S. Structural and biochemical elucidation of mechanism for decarboxylative condensation of β-keto acid by curcumin synthase. J. Biol. Chem. 286 (2011) 6659–6668. [PMID: 21148316]
[EC created 2013]