ExplorEnz: EC 2.3.1.221

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2.3.1.221

Accepted name:

noranthrone synthase

Reaction:

7 malonyl-CoA + hexanoyl-[acyl-carrier protein] = 7 CoA + norsolorinic acid anthrone + [acyl-carrier protein] + 7 CO₂ + 2 H₂O

For diagram of polyketides biosynthesis, click here

Glossary:

norsolorinic acid anthrone = noranthrone = 2-hexanoyl-1,3,6,8-tetrahydroxyanthracen-9(10H)-one

Other name(s):

polyketide synthase A (ambiguous); PksA (ambiguous); norsolorinic acid anthrone synthase

Systematic name:

malonyl-CoA:hexanoate malonyltransferase (norsolorinic acid anthrone-forming)

Comments:

A multi-domain polyketide synthase involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus. The hexanoyl starter unit is provided to the acyl-carrier protein (ACP) domain by a dedicated fungal fatty acid synthase [1].

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Crawford, J.M., Thomas, P.M., Scheerer, J.R., Vagstad, A.L., Kelleher, N.L. and Townsend, C.A. Deconstruction of iterative multidomain polyketide synthase function. Science 320 (2008) 243–246. [DOI] [PMID: 18403714]
2.	Crawford, J.M., Korman, T.P., Labonte, J.W., Vagstad, A.L., Hill, E.A., Kamari-Bidkorpeh, O., Tsai, S.C. and Townsend, C.A. Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization. Nature 461 (2009) 1139–1143. [DOI] [PMID: 19847268]
3.	Korman, T.P., Crawford, J.M., Labonte, J.W., Newman, A.G., Wong, J., Townsend, C.A. and Tsai, S.C. Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis. Proc. Natl. Acad. Sci. USA 107 (2010) 6246–6251. [DOI] [PMID: 20332208]

[EC 2.3.1.221 created 2013]