The Enzyme Database

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Accepted name: protein S-acyltransferase
Reaction: palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA
Other name(s): DHHC palmitoyl transferase; S-protein acyltransferase; G-protein palmitoyltransferase
Systematic name: palmitoyl-CoA:[protein]-L-cysteine S-palmitoyltransferase
Comments: The enzyme catalyses the posttranslational protein palmitoylation that plays a role in protein-membrane interactions, protein trafficking, and enzyme activity. Palmitoylation increases the hydrophobicity of proteins or protein domains and contributes to their membrane association.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB
1.  Dunphy, J.T., Greentree, W.K., Manahan, C.L. and Linder, M.E. G-protein palmitoyltransferase activity is enriched in plasma membranes. J. Biol. Chem. 271 (1996) 7154–7159. [DOI] [PMID: 8636152]
2.  Veit, M., Dietrich, L.E. and Ungermann, C. Biochemical characterization of the vacuolar palmitoyl acyltransferase. FEBS Lett. 540 (2003) 101–105. [DOI] [PMID: 12681491]
3.  Batistic, O. Genomics and localization of the Arabidopsis DHHC-cysteine-rich domain S-acyltransferase protein family. Plant Physiol. 160 (2012) 1597–1612. [DOI] [PMID: 22968831]
4.  Jennings, B.C. and Linder, M.E. DHHC protein S-acyltransferases use similar ping-pong kinetic mechanisms but display different acyl-CoA specificities. J. Biol. Chem. 287 (2012) 7236–7245. [DOI] [PMID: 22247542]
5.  Zhou, L.Z., Li, S., Feng, Q.N., Zhang, Y.L., Zhao, X., Zeng, Y.L., Wang, H., Jiang, L. and Zhang, Y. Protein S-acyl transferase10 is critical for development and salt tolerance in Arabidopsis. Plant Cell 25 (2013) 1093–1107. [DOI] [PMID: 23482856]
[EC created 2013]

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