The Enzyme Database

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Accepted name: tetracenomycin F2 synthase
Reaction: 10 malonyl-CoA = tetracenomycin F2 + 10 CoA + 10 CO2 + 2 H2O
For diagram of polyketides biosynthesis, click here
Glossary: tetracenomycin F2 = 4-(3-acetyl-4,5,7,10-tetrahydroxyanthracen-2-yl)-3-oxobutanoic acid
Other name(s): TCM PKS
Systematic name: malonyl-CoA:acetate malonyltransferase (tetracenomycin-F2-forming)
Comments: A multi-domain polyketide synthase involved in the synthesis of tetracenomycin in the bacterium Streptomyces glaucescens. It involves a ketosynthase complex (TcmKL), an acyl carrier protein (TcmM), a malonyl CoA:ACP acyltransferase (MAT), and a cyclase (TcmN). A malonyl-CoA molecule is initially bound to the acyl carrier protein and decarboxylated to form an acetyl starter unit. Additional two-carbon units are added from nine more malonyl-CoA molecules.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Bao, W., Wendt-Pienkowski, E. and Hutchinson, C.R. Reconstitution of the iterative type II polyketide synthase for tetracenomycin F2 biosynthesis. Biochemistry 37 (1998) 8132–8138. [DOI] [PMID: 9609708]
[EC created 2014]

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