| EC |
2.3.1.245 |
| Accepted name: |
3-hydroxy-5-phosphooxypentane-2,4-dione thiolase |
| Reaction: |
glycerone phosphate + acetyl-CoA = 3-hydroxy-2,4-dioxopentyl phosphate + CoA |
| Glossary: |
(4S)-4,5-dihydroxypentane-2,3-dione = autoinducer 2 = AI-2 |
| Other name(s): |
lsrF (gene name); 3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase |
| Systematic name: |
acetyl-CoA:glycerone phosphate C-acetyltransferase |
| Comments: |
The enzyme participates in a degradation pathway of the bacterial quorum-sensing autoinducer molecule AI-2. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Diaz, Z., Xavier, K.B. and Miller, S.T. The crystal structure of the Escherichia coli autoinducer-2 processing protein LsrF. PLoS One 4:e6820 (2009). [DOI] [PMID: 19714241] |
| 2. |
Marques, J.C., Oh, I.K., Ly, D.C., Lamosa, P., Ventura, M.R., Miller, S.T. and Xavier, K.B. LsrF, a coenzyme A-dependent thiolase, catalyzes the terminal step in processing the quorum sensing signal autoinducer-2. Proc. Natl. Acad. Sci. USA 111 (2014) 14235–14240. [DOI] [PMID: 25225400] |
|
| [EC 2.3.1.245 created 2015, modified 2021] |
| |
|
| |
|
Printable version