| EC |
2.3.1.285 |
| Accepted name: |
(13S,14R)-1,13-dihydroxy-N-methylcanadine 13-O-acetyltransferase |
| Reaction: |
acetyl-CoA + (13S,14R)-1,13-dihydroxy-cis-N-methylcanadine = (13S,14R)-13-O-acetyl-1-hydroxy-cis-N-methylcanadine + CoA |
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For diagram of noscapine biosynthesis, click here |
| Other name(s): |
AT1 (gene name) |
| Systematic name: |
acetyl-CoA:(13S,14R)-1,13-dihydroxy-cis-N-methylcanadine O-acetyltransferase |
| Comments: |
The enzyme, characterized from the plant Papaver somniferum (opium poppy), participates in the biosynthesis of the isoquinoline alkaloid noscapine. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Dang, T.T., Chen, X. and Facchini, P.J. Acetylation serves as a protective group in noscapine biosynthesis in opium poppy. Nat. Chem. Biol. 11 (2015) 104–106. [DOI] [PMID: 25485687] |
| 2. |
Li, Y., Li, S., Thodey, K., Trenchard, I., Cravens, A. and Smolke, C.D. Complete biosynthesis of noscapine and halogenated alkaloids in yeast. Proc. Natl. Acad. Sci. USA 115 (2018) E3922–E3931. [DOI] [PMID: 29610307] |
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| [EC 2.3.1.285 created 2019] |
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