The Enzyme Database

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Accepted name: (13S,14R)-1,13-dihydroxy-N-methylcanadine 13-O-acetyltransferase
Reaction: acetyl-CoA + (13S,14R)-1,13-dihydroxy-cis-N-methylcanadine = (13S,14R)-13-O-acetyl-1-hydroxy-cis-N-methylcanadine + CoA
For diagram of noscapine biosynthesis, click here
Other name(s): AT1 (gene name)
Systematic name: acetyl-CoA:(13S,14R)-1,13-dihydroxy-cis-N-methylcanadine O-acetyltransferase
Comments: The enzyme, characterized from the plant Papaver somniferum (opium poppy), participates in the biosynthesis of the isoquinoline alkaloid noscapine.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Dang, T.T., Chen, X. and Facchini, P.J. Acetylation serves as a protective group in noscapine biosynthesis in opium poppy. Nat. Chem. Biol. 11 (2015) 104–106. [DOI] [PMID: 25485687]
2.  Li, Y., Li, S., Thodey, K., Trenchard, I., Cravens, A. and Smolke, C.D. Complete biosynthesis of noscapine and halogenated alkaloids in yeast. Proc. Natl. Acad. Sci. USA 115 (2018) E3922–E3931. [DOI] [PMID: 29610307]
[EC created 2019]

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