| EC |
2.3.1.291 |
| Accepted name: |
sphingoid base N-palmitoyltransferase |
| Reaction: |
palmitoyl-CoA + a sphingoid base = an N-(palmitoyl)-sphingoid base + CoA |
| Other name(s): |
mammalian ceramide synthase 5; CERS5 (gene name); LASS5 (gene name) |
| Systematic name: |
palmitoyl-CoA:sphingoid base N-palmitoyltransferase |
| Comments: |
Mammals have six ceramide synthases that exhibit relatively strict specificity regarding the chain-length of their acyl-CoA substrates. Ceramide synthase 5 (CERS5) is specific for palmitoyl-CoA as the acyl donor. It can use multiple sphingoid bases including sphinganine, sphingosine, and phytosphingosine. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Lahiri, S. and Futerman, A.H. LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor. J. Biol. Chem. 280 (2005) 33735–33738. [PMID: 16100120] |
| 2. |
Xu, Z., Zhou, J., McCoy, D.M. and Mallampalli, R.K. LASS5 is the predominant ceramide synthase isoform involved in de novo sphingolipid synthesis in lung epithelia. J. Lipid Res. 46 (2005) 1229–1238. [PMID: 15772421] |
| 3. |
Mizutani, Y., Kihara, A. and Igarashi, Y. Mammalian Lass6 and its related family members regulate synthesis of specific ceramides. Biochem. J. 390 (2005) 263–271. [PMID: 15823095] |
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| [EC 2.3.1.291 created 2019, modified 2019] |
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