| EC |
2.3.1.309 |
| Accepted name: |
[β-tubulin]-L-lysine N-acetyltransferase |
| Reaction: |
acetyl-CoA + a [β-tubulin]-L-lysine = CoA + a [β-tubulin]-N6-acetyl-L-lysine |
| Other name(s): |
San; NatE; NAA50 (gene name) |
| Systematic name: |
acetyl-CoA:[β-tubulin]-L-lysine N6-acetyltransferase |
| Comments: |
The enzyme acetylates L-lysine at position 252 of β-tubulin, which is located at the interface of α/β-tubulin heterodimers and interacts with the phosphate group of the α-tubulin-bound GTP. The acetylation is thought to attenuate tubulin incorporation into microtubules. The enzyme catalysing this activity (NAA50) also catalyses the acetylation of certain N-terminal methionyl residues. That activity is classified as EC 2.3.1.258, N-terminal methionine Nα-acetyltransferase NatE. cf. EC 2.3.1.108, α-tubulin N-acetyltransferase. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Chu, C.W., Hou, F., Zhang, J., Phu, L., Loktev, A.V., Kirkpatrick, D.S., Jackson, P.K., Zhao, Y. and Zou, H. A novel acetylation of β-tubulin by San modulates microtubule polymerization via down-regulating tubulin incorporation. Mol. Biol. Cell 22 (2011) 448–456. [DOI] [PMID: 21177827] |
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| [EC 2.3.1.309 created 2022] |
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