ExplorEnz: EC 2.3.1.318

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2.3.1.318

Accepted name:

3-oxoadipate:acetyl-CoA acetyltransferase

Reaction:

3-oxoadipate + acetyl-CoA = acetoacetate + succinyl-CoA

Glossary:

3-oxoadipate = β-ketoadipate = 3-oxohexanedioate

Other name(s):

3-oxoadipate cleavage enzyme

Systematic name:

3-oxoadipate:acetyl-CoA acetyltransferase

Comments:

The enzyme, characterized from the bacteria Pseudomonas aeruginosa and Cupriavidus necator H16, belongs to a class of enzymes known as β-keto acid cleavage enzymes (BKACE). cf. EC 2.3.1.247, (5S)-5-amino-3-oxohexanoate:acetyl-CoA ethylamine transferase, EC 2.3.1.317, 3-dehydrocarnitine:acetyl-CoA trimethylamine transferase, and EC 2.3.1.319, 3,5-dioxohexanoate:acetyl-CoA acetone transferase.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc

References:

Bastard, K., Smith, A.A., Vergne-Vaxelaire, C., Perret, A., Zaparucha, A., De Melo-Minardi, R., Mariage, A., Boutard, M., Debard, A., Lechaplais, C., Pelle, C., Pellouin, V., Perchat, N., Petit, J.L., Kreimeyer, A., Medigue, C., Weissenbach, J., Artiguenave, F., De Berardinis, V., Vallenet, D. and Salanoubat, M. Revealing the hidden functional diversity of an enzyme family. Nat. Chem. Biol. 10 (2014) 42–49. [DOI] [PMID: 24240508]

[EC 2.3.1.318 created 2024]