ExplorEnz: EC 2.3.1.321

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2.3.1.321

Accepted name:

3′-N-debenzoyltaxol N-benzoyltransferase

Reaction:

benzoyl-CoA + 3′-N-debenzoyltaxol = CoA + paclitaxel

Other name(s):

DBTNBT; 3′-N-debenzoyl-2′-deoxytaxol N-benzoyltransferase

Systematic name:

benzoyl-CoA:3′-N-debenzoyltaxol 3′-N-benzoyltransferase

Comments:

The enzyme, present in Taxus species (yew) catalyses the final step in paclitaxel (Taxol) biosynthesis.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Walker, K., Long, R. and Croteau, R. The final acylation step in taxol biosynthesis: cloning of the taxoid C₁₃-side-chain N-benzoyltransferase from Taxus. Proc. Natl. Acad. Sci. USA 99 (2002) 9166–9171. [DOI] [PMID: 12089320]
2.	Long, R.M., Lagisetti, C., Coates, R.M. and Croteau, R.B. Specificity of the N-benzoyl transferase responsible for the last step of Taxol biosynthesis. Arch. Biochem. Biophys. 477 (2008) 384–389. [DOI] [PMID: 18621016]
3.	Zhang, Y., Wiese, L., Fang, H., Alseekh, S., Perez de Souza, L., Scossa, F., Molloy, J., Christmann, M. and Fernie, A.R. Synthetic biology identifies the minimal gene set required for paclitaxel biosynthesis in a plant chassis. Mol. Plant 16 (2023) 1951–1961. [DOI] [PMID: 37897038]

[EC 2.3.1.321 created 2024]