ExplorEnz: EC 2.3.1.326

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2.3.1.326

Accepted name:

(19E)-17,18-epoxy-17-hydroxycur-19-ene N-acetyltransferase

Reaction:

acetyl-CoA + (19E)-17,18-epoxy-17-hydroxycur-19-ene = CoA + diaboline

Glossary:

(19E)-17,18-epoxy-17-hydroxycur-19-ene = 18-hydroxycur-19-en-17-al = Wieland-Gumlich aldehyde
diaboline = (17R)-1-acetyl-17,18-epoxy-17-hydroxycur-19-ene

Other name(s):

Wieland-Gumlich aldehyde N-acetyltransferase

Systematic name:

acetyl-CoA:(19E)-17,18-epoxy-17-hydroxycur-19-ene N-acetyltransferase

Comments:

The enzyme has been characterized from a nonstrychnine-producing Strychnos sp. (Strychnos potatorum).

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Singh, H., Kapoor, V.K., Phillipson, J.D. and Bisset, N.G. Diaboline from Strychnos potatorum. Phytochemistry 14 (1975) 587–588. [DOI]
2.	Hong, B., Grzech, D., Caputi, L., Sonawane, P., Lopez, C.ER., Kamileen, M.O., Hernandez Lozada, N.J., Grabe, V. and O'Connor, S.E. Biosynthesis of strychnine. Nature 607 (2022) 617–622. [DOI] [PMID: 35794473]

[EC 2.3.1.326 created 2024]