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Your query returned 1 entry. 
Printable version
| EC | 2.3.1.330 | ||||
| Accepted name: | D-xylulose 5-phosphate:acyl-carrier protein glycolyltransferase system | ||||
| Reaction: | D-xylulose 5-phosphate + [acp] + a [lipoyl-carrier protein]-N6-[(R)-lipoyl]-L-lysine = D-glyceraldehyde 3-phosphate + glycolyl-[acp] + a [lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine (overall reaction) (1a) D-xylulose 5-phosphate + a [lipoyl-carrier protein]-N6-[(R)-lipoyl]-L-lysine = D-glyceraldehyde 3-phosphate + a [lipoyl-carrier protein]-N6-[glycolyl-(R)-dihydrolipoyl]-L-lysine (1b) a [lipoyl-carrier protein]-N6-[glycolyl-(R)-dihydrolipoyl]-L-lysine + [acp] = glycolyl-[acp] + a [lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine |
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| Other name(s): | sclQ1/sclQ2/sclQ3 (gene names); napB/napD (gene names); QncN/QncL (gene names) | ||||
| Systematic name: | D-xylulose 5-phosphate:acyl-carrier protein glycolyltransferase | ||||
| Comments: | This enzyme system produces glycolyl-[acp] units that can be used by non-ribosomal peptide synthases. It catalyses a transketolase-like reaction on ketose phosphates derived from primary metabolism and transfers the resulting glycolyl moiety to a dedicated acyl-carrier protein. During the reaction cycle the glycolyl moiety is transferred first to a thiamine diphosphate cofactor, then to a lipoyl cofactor, and eventually to the acyl-carrier protein. While D-xylulose 5-phosphate is the best substrate, the enzyme can also accept D-fructose 6-phosphate and D-sedheptulose 7-phosphate. During the reaction the lipoyl cofactor is reduced to dihydrolipoyl, which must be oxidized back to lipoyl by an unknown enzyme. | ||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
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