ExplorEnz: EC 2.3.1.331

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2.3.1.331

Accepted name:

phenylglycine N-acetyltransferase

Reaction:

acetyl-CoA + L-phenylglycine = (2S)-2-acetylamino-2-phenylacetic acid + CoA

Other name(s):

natA (gene name)

Systematic name:

acetyl-CoA:L-phenylgylcine N-acetyltransferase

Comments:

The enzyme has been isolated from the bacterium Chryseobacterium sp. 5-3B. Reduced activity has been observed with L-2-phenylglycine methyl ester, L-2-chlorophenylglycine and L-4-hydroxyphenylglycine.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Takenaka, S., Honma, Y., Yoshida, K. and Yoshida, K. Enantioselective N-acetylation of 2-phenylglycine by an unusual N-acetyltransferase from Chryseobacterium sp. Biotechnol. Lett. 35 (2013) 1053–1059. [DOI] [PMID: 23479412]
2.	Takenaka, S., Yoshida, K., Tanaka, K. and Yoshida, K. Molecular characterization of a novel N-acetyltransferase from Chryseobacterium sp. Appl. Environ. Microbiol. 80 (2014) 1770–1776. [DOI] [PMID: 24375143]
3.	Takenaka, S., Ozeki, T., Tanaka, K. and Yoshida, K.I. Homology modeling and prediction of the amino acid residues participating in the transfer of acetyl-CoA to arylalkylamine by the N-acetyltransferase from Chryseobacterium sp. Biotechnol. Lett. 39 (2017) 1699–1707. [DOI] [PMID: 28721586]

[EC 2.3.1.331 created 2025]