ExplorEnz: EC 2.3.1.334

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2.3.1.334

Accepted name:

cocaine synthase

Reaction:

benzoyl-CoA + ecgonine methyl ester = CoA + cocaine

Systematic name:

benzoyl-CoA:ecgonine methyl ester O-benzoyltransferase

Comments:

Isolated from the plant Erythoxylum coca. Cinnamoyl-CoA can substitute for benzoyl-CoA.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Schmidt, G.W., Jirschitzka, J., Porta, T., Reichelt, M., Luck, K., Torre, J.C., Dolke, F., Varesio, E., Hopfgartner, G., Gershenzon, J. and D'Auria, J.C. The last step in cocaine biosynthesis is catalyzed by a BAHD acyltransferase. Plant Physiol. 167 (2015) 89–101. [DOI] [PMID: 25406120]

[EC 2.3.1.334 created 2025]