ExplorEnz: EC 2.3.1.337

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2.3.1.337

Accepted name:

conjugated bile acid:L-amino acid N-acyltransferase

Reaction:

(1) glycocholate + an L-amino acid = an amino acid—bile acid amidate + glycine
(2) taurocholate + an L-amino acid = an amino acid—bile acid amidate + taurine

Other name(s):

bsh (gene name)

Systematic name:

conjugated bile acid:L-amino acid N-acyltransferase

Comments:

Amino acid—bile acid amidates are formed in the gastrointestinal tract from bile acid conjugates of glycine or taurine. This is a second activity of the bacterial enzyme EC 3.5.1.24, choloylglycine hydrolase (also known as bile salt hydrolase).

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

Rimal, B., Collins, S.L., Tanes, C.E., Rocha, E.R., Granda, M.A., Solanki, S., Hoque, N.J., Gentry, E.C., Koo, I., Reilly, E.R., Hao, F., Paudel, D., Singh, V., Yan, T., Kim, M.S., Bittinger, K., Zackular, J.P., Krausz, K.W., Desai, D., Amin, S., Coleman, J.P., Shah, Y.M., Bisanz, J.E., Gonzalez, F.J., Vanden Heuvel, J.P., Wu, G.D., Zemel, B.S., Dorrestein, P.C., Weinert, E.E. and Patterson, A.D. Bile salt hydrolase catalyses formation of amine-conjugated bile acids. Nature 626 (2024) 859–863. [DOI] [PMID: 38326609]

[EC 2.3.1.337 created 2026]