EC |
2.3.1.37 |
Accepted name: |
5-aminolevulinate synthase |
Reaction: |
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 |
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For diagram of the early stages of porphyrin biosynthesis, click here |
Other name(s): |
ALAS; ALA synthase; α-aminolevulinic acid synthase; δ-aminolevulinate synthase; δ-aminolevulinate synthetase; δ-aminolevulinic acid synthase; δ-aminolevulinic acid synthetase; δ-aminolevulinic synthetase; 5-aminolevulinate synthetase; 5-aminolevulinic acid synthetase; ALA synthetase; aminolevulinate synthase; aminolevulinate synthetase; aminolevulinic acid synthase; aminolevulinic acid synthetase; aminolevulinic synthetase |
Systematic name: |
succinyl-CoA:glycine C-succinyltransferase (decarboxylating) |
Comments: |
A pyridoxal-phosphate protein. The enzyme in erythrocytes is genetically distinct from that in other tissues. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9037-14-3 |
References: |
1. |
Bishop, D.F., Henderson, A.S. and Astrin, K.H. Human δ-aminolevulinate synthase - assignment of the housekeeping gene to 3p21 and the erythroid-specific gene to the X-chromosome. Genomics 7 (1990) 207–214. [PMID: 2347585] |
2. |
Kikuchi, G., Kumar, A., Talmage, P. and Shemin, D. The enzymatic synthesis of δ-aminolevulinic acid. J. Biol. Chem. 233 (1958) 1214–1219. [PMID: 13598764] |
3. |
Ramaswamy, N.K. and Nair, P.M. δ-Aminolevulinic acid synthetase from cold-stored potatoes. Biochim. Biophys. Acta 293 (1973) 269–277. [PMID: 4685279] |
4. |
Scholnick, P.L., Hammaker, L.E. and Marver, H.S. Soluble δ-aminolevulinic acid synthetase of rat liver. I. Some properties of the partially purified enzyme. J. Biol. Chem. 247 (1972) 4126–4131. [PMID: 4624703] |
5. |
Scholnick, P.L., Hammaker, L.E. and Marver, H.S. Soluble δ-aminolevulinic acid synthetase of rat liver. II. Studies related to the mechanism of enzyme action and hemin inhibition. J. Biol. Chem. 247 (1972) 4132–4137. [PMID: 5035685] |
6. |
Tait, G.H. Aminolaevulinate synthetase of Micrococcus denitrificans. Purification and properties of the enzyme, and the effect of growth conditions on the enzyme activity in cells. Biochem. J. 131 (1973) 389–403. [PMID: 4722442] |
7. |
Warnick, G.R. and Burnham, B.F. Regulation of porphyrin biosynthesis. Purification and characterization of δ-aminolevulinic acid synthase. J. Biol. Chem. 246 (1971) 6880–6885. [PMID: 5315997] |
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[EC 2.3.1.37 created 1972] |
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