The Enzyme Database

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Accepted name: serine C-palmitoyltransferase
Reaction: palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2
Other name(s): serine palmitoyltransferase; SPT; 3-oxosphinganine synthetase; acyl-CoA:serine C-2 acyltransferase decarboxylating
Systematic name: palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating)
Comments: A pyridoxal-phosphate protein.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 62213-50-7
1.  Brady, R.N., DiMari, S.J. and Snell, E.E. Biosynthesis of sphingolipid bases. 3. Isolation and characterization of ketonic intermediates in the synthesis of sphingosine and dihydrosphingosine by cell-free extracts of Hansenula ciferri. J. Biol. Chem. 244 (1969) 491–496. [PMID: 4388074]
2.  Stoffel, W., Le Kim, D. and Sticht, G. Biosynthesis of dihydrosphingosine in vitro. Hoppe-Seyler's Z. Physiol. Chem. 349 (1968) 664–670. [PMID: 4386961]
[EC created 1976, modified 1982]

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