| EC |
2.3.1.50 |
| Accepted name: |
serine C-palmitoyltransferase |
| Reaction: |
palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2 |
| Other name(s): |
serine palmitoyltransferase; SPT; 3-oxosphinganine synthetase; acyl-CoA:serine C-2 acyltransferase decarboxylating |
| Systematic name: |
palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) |
| Comments: |
A pyridoxal-phosphate protein. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 62213-50-7 |
| References: |
| 1. |
Brady, R.N., DiMari, S.J. and Snell, E.E. Biosynthesis of sphingolipid bases. 3. Isolation and characterization of ketonic intermediates in the synthesis of sphingosine and dihydrosphingosine by cell-free extracts of Hansenula ciferri. J. Biol. Chem. 244 (1969) 491–496. [PMID: 4388074] |
| 2. |
Stoffel, W., Le Kim, D. and Sticht, G. Biosynthesis of dihydrosphingosine in vitro. Hoppe-Seyler's Z. Physiol. Chem. 349 (1968) 664–670. [PMID: 4386961] |
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| [EC 2.3.1.50 created 1976, modified 1982] |
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