EC |
2.3.1.6 |
Accepted name: |
choline O-acetyltransferase |
Reaction: |
acetyl-CoA + choline = CoA + O-acetylcholine |
Other name(s): |
choline acetylase; choline acetyltransferase |
Systematic name: |
acetyl-CoA:choline O-acetyltransferase |
Comments: |
Propanoyl-CoA can act, more slowly, in place of acetyl-CoA. |
Links to other databases: |
BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9012-78-6 |
References: |
1. |
Berman, R., Wilson, I.B. and Nachmansohn, D. Choline acetylase specificity in relation to biological function. Biochim. Biophys. Acta 12 (1953) 315–324. [DOI] [PMID: 13115440] |
2. |
Berry, J.F. and Whittaker, V.P. The acyl-group specificity of choline acetylase. Biochem. J. 73 (1959) 447–458. [PMID: 13799882] |
3. |
Fritz, I.B. and Schultz, S.K. Carnitine acetyltransferase. II. Inhibition by carnitine analogues and by sulfhydryl reagents. J. Biol. Chem. 240 (1965) 2188–2192. [PMID: 14299645] |
4. |
Schuberth, J. Choline acetyltransferase. Purification and effect of salts on the mechanism of the enzyme-catalysed reaction. Biochim. Biophys. Acta 122 (1966) 470–481. |
|
[EC 2.3.1.6 created 1961] |
|
|
|
|