| EC |
2.3.1.60 |
| Accepted name: |
gentamicin 3-N-acetyltransferase |
| Reaction: |
acetyl-CoA + gentamicin C = CoA + N3-acetylgentamicin C |
| Other name(s): |
gentamycin acetyltransferase I; aminoglycoside acetyltransferase AAC(3)-1; gentamycin 3-N-acetyltransferase; acetyl-CoA:gentamycin-C N3-acetyltransferase; acetyl-CoA:gentamicin-C N3′-acetyltransferase (incorrect); gentamicin 3′-N-acetyltransferase (incorrect) |
| Systematic name: |
acetyl-CoA:gentamicin-C N3-acetyltransferase |
| Comments: |
Also acetylates sisomicin. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 58500-58-6 |
| References: |
| 1. |
Angelatou, F., Litsas, S.B. and Kontomichalou, P. Purification and properties of two gentamicin-modifying enzymes, coded by a single plasmid pPK237 originating from Pseudomonas aeruginosa. J. Antibiot. 35 (1982) 235–244. [PMID: 6281224] |
| 2. |
Biddlecome, S., Haas, J., Davies, G.H., Miller, D., Rane, F. and Daniels, P.J.L. Enzymatic modification of aminoglycoside antibiotics: a new 3-N-acetylating enzyme from a Pseudomonas aeruginosa isolate. Antimicrob. Agents Chemother. 9 (1976) 951–955. [PMID: 820250] |
| 3. |
Williams, J.W. and Northrop, D.B. Purification and properties of gentamicin acetyltransferase I. Biochemistry 15 (1976) 125–131. [PMID: 764855] |
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| [EC 2.3.1.60 created 1976, modified 2015] |
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