The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

Accepted name: gentamicin 3-N-acetyltransferase
Reaction: acetyl-CoA + gentamicin C = CoA + N3-acetylgentamicin C
Other name(s): gentamycin acetyltransferase I; aminoglycoside acetyltransferase AAC(3)-1; gentamycin 3-N-acetyltransferase; acetyl-CoA:gentamycin-C N3-acetyltransferase; acetyl-CoA:gentamicin-C N3′-acetyltransferase (incorrect); gentamicin 3′-N-acetyltransferase (incorrect)
Systematic name: acetyl-CoA:gentamicin-C N3-acetyltransferase
Comments: Also acetylates sisomicin.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 58500-58-6
1.  Angelatou, F., Litsas, S.B. and Kontomichalou, P. Purification and properties of two gentamicin-modifying enzymes, coded by a single plasmid pPK237 originating from Pseudomonas aeruginosa. J. Antibiot. 35 (1982) 235–244. [PMID: 6281224]
2.  Biddlecome, S., Haas, J., Davies, G.H., Miller, D., Rane, F. and Daniels, P.J.L. Enzymatic modification of aminoglycoside antibiotics: a new 3-N-acetylating enzyme from a Pseudomonas aeruginosa isolate. Antimicrob. Agents Chemother. 9 (1976) 951–955. [PMID: 820250]
3.  Williams, J.W. and Northrop, D.B. Purification and properties of gentamicin acetyltransferase I. Biochemistry 15 (1976) 125–131. [PMID: 764855]
[EC created 1976, modified 2015]

Data © 2001–2024 IUBMB
Web site © 2005–2024 Andrew McDonald