EC |
2.3.1.81 |
Accepted name: |
aminoglycoside 3-N-acetyltransferase |
Reaction: |
acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N3-acetyl-2-deoxystreptamine antibiotic |
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For diagram of neamine and ribostamycin biosynthesis, click here |
Glossary: |
kanamycin |
Other name(s): |
3-aminoglycoside acetyltransferase; 3-N-aminoglycoside acetyltransferase; aminoglycoside N3-acetyltransferase; acetyl-CoA:2-deoxystreptamine-antibiotic N3′-acetyltransferase (incorrect); aminoglycoside N3′-acetyltransferase (incorrect) |
Systematic name: |
acetyl-CoA:2-deoxystreptamine-antibiotic N3-acetyltransferase |
Comments: |
Different from EC 2.3.1.60 gentamicin 3-N-acetyltransferase. A wide range of antibiotics containing the 2-deoxystreptamine ring can act as acceptors, including gentamicin, kanamycin, tobramycin, neomycin and apramycin. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 60120-42-5 |
References: |
1. |
Davies, J. and O'Connor, S. Enzymatic modification of aminoglycoside antibiotics: 3-N-Acetyltransferase with broad specificity that determines resistance to the novel aminoglycoside apramycin. Antimicrob. Agents Chemother. 14 (1978) 69–72. [PMID: 356726] |
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[EC 2.3.1.81 created 1984, modified 2015] |
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