The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

Accepted name: aminoglycoside 6′-N-acetyltransferase
Reaction: acetyl-CoA + kanamycin-B = CoA + N6′-acetylkanamycin-B
Glossary: kanamycin
Other name(s): aminoglycoside N6′-acetyltransferase; aminoglycoside-6′-acetyltransferase; aminoglycoside-6-N-acetyltransferase; kanamycin acetyltransferase
Systematic name: acetyl-CoA:kanamycin-B N6′-acetyltransferase
Comments: The antibiotics kanamycin A, kanamycin B, neomycin, gentamicin C1a, gentamicin C2 and sisomicin are substrates. The antibiotic tobramycin, but not paromomycin, can also act as acceptor. The 6-amino group of the purpurosamine ring is acetylated.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 56467-65-3
1.  le Goffic, F. and Martel, A. La résistance aux aminosides provoquée par une isoenzyme la kanamycine acétyltransférase. Biochimie 56 (1974) 893–897. [DOI] [PMID: 4614862]
2.  Benveniste, R. and Davies, J.E. Enzymatic acetylation of aminoglycoside antibiotics by Escherichia coli carrying an R factor. Biochemistry 10 (1971) 1787–1796. [PMID: 4935296]
3.  Dowding, J.E. Mechanisms of gentamicin resistance in Staphylococcus aureus. Antimicrob. Agents Chemother. 11 (1977) 47–50. [PMID: 836013]
[EC created 1976 as EC, transferred 1999 to EC, modified 1999, modified 2015]

Data © 2001–2024 IUBMB
Web site © 2005–2024 Andrew McDonald