ExplorEnz: EC 2.3.2.1

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2.3.2.1

Accepted name:

D-glutamyltransferase

Reaction:

(1) D-glutamine + D-glutamate = NH₃ + γ-D-glutamyl-D-glutamate
(2) L(or D)-glutamine + (γ-D-glutamyl)_n-[peptide] = NH₃ + (γ-D-glutamyl)_n+1-[peptide]

Other name(s):

D-glutamyl transpeptidase; D-γ-glutamyl transpeptidase

Systematic name:

glutamine:D-glutamyl-peptide 5-glutamyltransferase

Comments:

The enzyme catalyses two reactions. The first is the transfer of a glutamyl residue from L- or D-glutamine to D-glutamate via a γ linkage, forming γ-glutamyl-D-glutamate, and the second is the transfer of additional glutamyl residues to the peptide, extending the polypeptide chain.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9030-02-8

References:

1.	Williams, W.J. and Thorne, C.B. Biosynthesis of glutamyl peptides from glutamine by a transfer reaction. J. Biol. Chem. 210 (1954) 203–217. [PMID: 13201582]
2.	Williams, W.J., Litwin, J. and Thorne, C.B. Further studies on the biosynthesis of γ-glutamyl peptides by transfer reactions. J. Biol. Chem. 212 (1955) 427–438. [PMID: 13233245]

[EC 2.3.2.1 created 1961, modified 1976, modified 2013]