| EC |
2.3.3.3 |
| Accepted name: |
citrate (Re)-synthase |
| Reaction: |
acetyl-CoA + H2O + oxaloacetate = citrate + CoA |
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For diagram of the reactions of the citrate synthases, click here |
| Other name(s): |
(R)-citrate synthase; Re-citrate-synthase; citrate oxaloacetate-lyase [(pro-3R)-CH2COO-→acetyl-CoA] |
| Systematic name: |
acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-R)-carboxymethyl-forming] |
| Comments: |
This enzyme is inactivated by oxygen and is found in some anaerobes. Its stereospecificity is opposite to that of EC 2.3.3.1, citrate (Si)-synthase. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, CAS registry number: 9077-70-7 |
| References: |
| 1. |
Dittbrenner, S., Chowdhury, A.A. and Gottschalk, G. The stereospecificity of the (R)-citrates synthase in the presence of p-chloromercuribenzoate. Biochem. Biophys. Res. Commun. 36 (1969) 802–808. [DOI] [PMID: 5808294] |
| 2. |
Gottschalk, G. Partial purification and some properties of the (R)-citrate synthase from Clostridium acidi-urici. Eur. J. Biochem. 7 (1969) 301–306. [DOI] [PMID: 4974734] |
| 3. |
Gottschalk, G. and Barker, H.A. Synthesis of glutamate and citrate by Clostridium kluyveri. A new type of citrate synthase. Biochemistry 5 (1966) 1125–1133. [PMID: 5958189] |
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| [EC 2.3.3.3 created 1972 as EC 4.1.3.28, transferred 2002 to EC 2.3.3.3] |
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