| EC |
2.4.1.110 |
| Accepted name: |
tRNA-queuosine α-mannosyltransferase |
| Reaction: |
GDP-α-D-mannose + queuosine34 in tRNAAsp = GDP + O-4′′-α-D-mannosylqueuosine34 in tRNAAsp |
| Other name(s): |
GDP-mannose:tRNAAsp-queuosine O-5′′-β-D-mannosyltransferase (incorrect); tRNA-queuosine β-mannosyltransferase (incorrect) |
| Systematic name: |
GDP-α-D-mannose:queuosine34 in tRNAAsp O-4′′-α-D-mannosyltransferase (configuration-retaining) |
| Comments: |
This enzyme, found in higher vertebrates, modifies tRNAAsp at the wobble position of the anticodon loop. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9055-06-5 |
| References: |
| 1. |
Okada, N. and Nishimura, S. Enzymatic synthesis of Q nucleoside containing mannose in the anticodon of tRNA: isolation of a novel mannosyltransferase from a cell-free extract of rat liver. Nucleic Acids Res. 4 (1977) 2931–2938. [DOI] [PMID: 20603] |
| 2. |
Hillmeier, M., Wagner, M., Ensfelder, T., Korytiakova, E., Thumbs, P., Muller, M. and Carell, T. Synthesis and structure elucidation of the human tRNA nucleoside mannosyl-queuosine. Nat. Commun. 12:7123 (2021). [DOI] [PMID: 34880214] |
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| [EC 2.4.1.110 created 1984, modified 2022] |
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