| EC |
2.4.1.153 |
| Accepted name: |
UDP-N-acetylglucosamine—dolichyl-phosphate N-acetylglucosaminyltransferase |
| Reaction: |
UDP-N-acetyl-α-D-glucosamine + dolichyl phosphate = UDP + dolichyl N-acetyl-α-D-glucosaminyl phosphate |
| Other name(s): |
aglK (gene name); dolichyl-phosphate α-N-acetylglucosaminyltransferase; UDP-N-acetyl-D-glucosamine:dolichyl-phosphate α-N-acetyl-D-glucosaminyltransferase |
| Systematic name: |
UDP-N-acetyl-α-D-glucosamine:dolichyl-phosphate α-N-acetyl-D-glucosaminyltransferase |
| Comments: |
The enzyme, characterized from the methanogenic archaeon Methanococcus voltae, initiates N-linked glycosylation in that organism. The enzyme differs from the eukaryotic enzyme, which leaves one additional phosphate group on the dolichyl product (cf. EC 2.7.8.15, UDP-N-acetylglucosamine—dolichyl-phosphate N-acetylglucosaminephosphotransferase). |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 63363-73-5 |
| References: |
| 1. |
Larkin, A., Chang, M.M., Whitworth, G.E. and Imperiali, B. Biochemical evidence for an alternate pathway in N-linked glycoprotein biosynthesis. Nat. Chem. Biol. 9 (2013) 367–373. [DOI] [PMID: 23624439] |
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| [EC 2.4.1.153 created 1984, modified 2015] |
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