| EC |
2.4.1.284 |
| Accepted name: |
2-deoxystreptamine glucosyltransferase |
| Reaction: |
UDP-α-D-glucose + 2-deoxystreptamine = UDP + 2′-deamino-2′-hydroxyparomamine |
| Glossary: |
2′-deamino-2′-hydroxyparomamine = 4-O-α-D-glucopyranosyl-2-deoxy-D-streptamine |
| Other name(s): |
kanF (gene name) |
| Systematic name: |
UDP-α-D-glucose:2-deoxystreptamine 6-α-D-glucosyltransferase |
| Comments: |
Involved in the biosynthesis of kanamycin B and kanamycin C. Also catalyses EC 2.4.1.283, 2-deoxystreptamine N-acetyl-D-glucosaminyltransferase, but activity is only one fifth of that with UDP-α-D-glucose. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Park, J.W., Park, S.R., Nepal, K.K., Han, A.R., Ban, Y.H., Yoo, Y.J., Kim, E.J., Kim, E.M., Kim, D., Sohng, J.K. and Yoon, Y.J. Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation. Nat. Chem. Biol. 7 (2011) 843–852. [DOI] [PMID: 21983602] |
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| [EC 2.4.1.284 created 2012] |
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