| EC |
2.4.1.338 |
| Accepted name: |
validoxylamine A glucosyltransferase |
| Reaction: |
UDP-α-D-glucose + validoxylamine A = UDP + validamycin A |
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For diagram of validamycin biosynthesis, click here |
| Glossary: |
validoxylamine A = (1S,2S,3R,6S)-4-(hydroxymethyl)-6-{[(1S,2S,3S,4R,5R)-2,3,4-trihydroxy-5-(hydroxymethyl)cyclohexyl]amino}cyclohex-4-ene-1,2,3-triol |
| Other name(s): |
vldK (gene name); valG (gene name) |
| Systematic name: |
UDP-α-D-glucose:validoxylamine-A 4′-O-glucosyltransferase |
| Comments: |
The enzyme, characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus, catalyses the ultimate step in the biosynthesis of the antifungal agent validamycin A. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Bai, L., Li, L., Xu, H., Minagawa, K., Yu, Y., Zhang, Y., Zhou, X., Floss, H.G., Mahmud, T. and Deng, Z. Functional analysis of the validamycin biosynthetic gene cluster and engineered production of validoxylamine A. Chem. Biol. 13 (2006) 387–397. [DOI] [PMID: 16632251] |
| 2. |
Xu, H., Minagawa, K., Bai, L., Deng, Z. and Mahmud, T. Catalytic analysis of the validamycin glycosyltransferase (ValG) and enzymatic production of 4′′-epi-validamycin A. J Nat Prod 71 (2008) 1233–1236. [DOI] [PMID: 18563934] |
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| [EC 2.4.1.338 created 2016] |
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