| EC |
2.4.1.366 |
| Accepted name: |
ginsenoside F1 6-O-glucosyltransferase |
| Reaction: |
UDP-α-D-glucose + ginsenoside F1 = UDP + (20S)-ginsenoside Rg1 |
| Glossary: |
ginsenoside F1 = 3β,6α,12β-trihydroxydammar-24-en-20-yl β-D-glucopyranoside |
| Other name(s): |
UGTPg101 (gene name) |
| Systematic name: |
UDP-α-D-glucose:ginsenoside F1 6-O-glucosyltransferase |
| Comments: |
The enzyme, characterized from the plant Panax ginseng, glucosylates the C-6 position of ginsenoside F1. The enzyme also glucosylates the C-20 position of protopanaxatriol, which forms ginsenoside F1 (cf. EC 2.4.1.363, ginsenoside 20-O-glucosyltransferase). However, unlike EC 2.4.1.367, ginsenoside 6-O-glucosyltransferase, it is not able to glucosylate the C-6 position of protopanaxatriol when position C-20 is not glucosylated. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Wei, W., Wang, P., Wei, Y., Liu, Q., Yang, C., Zhao, G., Yue, J., Yan, X. and Zhou, Z. Characterization of Panax ginseng UDP-glycosyltransferases catalyzing protopanaxatriol and biosyntheses of bioactive ginsenosides F1 and Rh1 in metabolically engineered yeasts. Mol. Plant 8 (2015) 1412–1424. [PMID: 26032089] |
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| [EC 2.4.1.366 created 2019] |
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