The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

EC 2.4.1.369     
Accepted name: enterobactin C-glucosyltransferase
Reaction: (1) UDP-α-D-glucose + enterobactin = UDP + monoglucosyl-enterobactin
(2) UDP-α-D-glucose + monoglucosyl-enterobactin = UDP + diglucosyl-enterobactin
(3) UDP-α-D-glucose + diglucosyl-enterobactin = UDP + triglucosyl-enterobactin
Glossary: enterobactin = N-(2,3-dihydroxybenzoyl)-O-[N-(2,3-dihydroxybenzoyl)-O-[N-(2,3-dihydroxybenzoyl)-L-seryl]-L-seryl]-L-serine-(3→1(3))-lactone
monoglucosyl-enterobactin = N-(2,3-dihydroxybenzoyl)-O-[N-(2,3-dihydroxybenzoyl)-O-[N-(5-β-D-glucopyranosyl-2,3-dihydroxybenzoyl)-L-seryl]-L-seryl]-L-serine-3→1(3)-lactone = mono-C-glucosyl-enterobactin = salmochelin MGE
diglucosyl-enterobactin = N-(2,3-dihydroxybenzoyl)-O-[N-(5-β-D-glucopyranosyl-2,3-dihydroxybenzoyl)-O-[N-(5-β-D-glucopyranosyl-2,3-dihydroxybenzoyl)-L-seryl]-L-seryl]-L-serine-(3→1(3))-lactone = salmochelin S4 = di-C-glucosyl-enterobactin
triglucosyl-enterobactin = N-(5-β-D-glucopyranosyl-2,3-dihydroxybenzoyl)-O-[N-(5-β-D-glucopyranosyl-2,3-dihydroxybenzoyl)-O-[N-(5-β-D-glucopyranosyl-2,3-dihydroxybenzoyl)-L-seryl]-L-seryl]-L-serine-(3→1(3))-lactone = tri-C-glucosyl-enterobactin = salmochelin TGE
Other name(s): iroB (gene name)
Systematic name: UDP-α-D-glucose:enterobactin 5′-C-β-D-glucosyltransferase (configuration-inverting)
Comments: The enzyme, found in pathogenic strains of the bacteria Escherichia coli and Salmonella enterica, catalyses the transfer of glucosyl groups to C-5 of one, two, or three of the 2,3-hydroxybenzoyl units of the siderophore enterobactin, forming C-glucosylated derivatives known as salmochelins.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Fischbach, M.A., Lin, H., Liu, D.R. and Walsh, C.T. In vitro characterization of IroB, a pathogen-associated C-glycosyltransferase. Proc. Natl. Acad. Sci. USA 102 (2005) 571–576. [PMID: 15598734]
[EC 2.4.1.369 created 2019]
 
 


Data © 2001–2024 IUBMB
Web site © 2005–2024 Andrew McDonald