ExplorEnz: EC 2.4.1.83

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2.4.1.83

Accepted name:

dolichyl-phosphate β-D-mannosyltransferase

Reaction:

GDP-α-D-mannose + dolichyl phosphate = GDP + dolichyl β-D-mannosyl phosphate

For diagram of glycoprotein biosynthesis, click here

Other name(s):

GDP-Man:DolP mannosyltransferase; dolichyl mannosyl phosphate synthase; dolichyl-phospho-mannose synthase; GDP-mannose:dolichyl-phosphate mannosyltransferase; guanosine diphosphomannose-dolichol phosphate mannosyltransferase; dolichol phosphate mannose synthase; dolichyl phosphate mannosyltransferase; dolichyl-phosphate mannose synthase; GDP-mannose-dolichol phosphate mannosyltransferase; GDP-mannose-dolichylmonophosphate mannosyltransferase; mannosylphosphodolichol synthase; mannosylphosphoryldolichol synthase

Systematic name:

GDP-mannose:dolichyl-phosphate β-D-mannosyltransferase

Comments:

Acts only on long-chain polyprenyl phosphates and α-dihydropolyprenyl phosphates that are larger than C₃₅.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 62213-44-9

References:

1.	Babczinski, P., Haselbeck, A. and Tanner, W. Yeast mannosyl transferases requiring dolichyl phosphate and dolichyl phosphate mannose as substrate. Partial purification and characterization of the solubilized enzyme. Eur. J. Biochem. 105 (1980) 509–515. [DOI] [PMID: 6989607]
2.	Bretthauer, R.K., Wu, S. and Irwin, W.E. Enzymatic transfer of mannose from guanosine diphosphate mannose to dolichol phosphate in yeast (Hansenula holstii). A possible step in mannan synthesis. Biochim. Biophys. Acta 304 (1973) 736–747. [DOI] [PMID: 4726855]
3.	Haselbeck, A. Purification of GDP mannose:dolichyl-phosphate O-β-D-mannosyltransferase from Saccharomyces cerevisiae. Eur. J. Biochem. 181 (1989) 663–668. [DOI] [PMID: 2659345]
4.	Palamarczyk, G., Lehle, L., Mankowski, T., Chojnacki, T. and Tanner, W. Specificity of solubilized yeast glycosyl transferases for polyprenyl derivatives. Eur. J. Biochem. 105 (1980) 517–523. [DOI] [PMID: 6445267]
5.	Richards, J.B. and Hemming, F.W. The transfer of mannose from guanosine diphosphate mannose to dolichol phosphate and protein by pig liver endoplasmic reticulum. Biochem. J. 130 (1972) 77–93. [PMID: 4655455]

[EC 2.4.1.83 created 1976, modified 1983]