EC |
2.4.2.4 |
Accepted name: |
thymidine phosphorylase |
Reaction: |
thymidine + phosphate = thymine + 2-deoxy-α-D-ribose 1-phosphate |
Other name(s): |
pyrimidine phosphorylase; thymidine-orthophosphate deoxyribosyltransferase; animal growth regulators, blood platelet-derived endothelial cell growth factors; blood platelet-derived endothelial cell growth factor; deoxythymidine phosphorylase; gliostatins; pyrimidine deoxynucleoside phosphorylase; thymidine:phosphate deoxy-D-ribosyltransferase |
Systematic name: |
thymidine:phosphate deoxy-α-D-ribosyltransferase |
Comments: |
The enzyme in some tissues also catalyses deoxyribosyltransferase reactions of the type catalysed by EC 2.4.2.6, nucleoside deoxyribosyltransferase. |
Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9030-23-3 |
References: |
1. |
Friedkin, M. and Roberts, D. The enzymatic synthesis of nucleosides. I. Thymidine phosphorylase in mammalian tissue. J. Biol. Chem. 207 (1954) 245–256. [PMID: 13152099] |
2. |
Zimmerman, M. and Seidenberg, J. Deoxyribosyl transfer. I. Thymidine phosphorylase and nucleoside deoxyribosyltransferase in normal and malignant tissues. J. Biol. Chem. 239 (1964) 2618–2621. [PMID: 14235544] |
3. |
Zimmerman, M. Deoxyribosyl transfer. II. Nucleoside:pyrimidine deoxyribosyltransferase activity of three partially purified thymidine phosphorylases. J. Biol. Chem. 239 (1964) 2622–2627. [PMID: 14235545] |
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[EC 2.4.2.4 created 1961] |
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