| EC |
2.4.2.44 |
| Accepted name: |
S-methyl-5′-thioinosine phosphorylase |
| Reaction: |
S-methyl-5′-thioinosine + phosphate = hypoxanthine + S-methyl-5-thio-α-D-ribose 1-phosphate |
| Other name(s): |
MTIP; MTI phosphorylase; methylthioinosine phosphorylase |
| Systematic name: |
S-methyl-5′-thioinosine:phosphate S-methyl-5-thio-α-D-ribosyl-transferase |
| Comments: |
No activity with S-methyl-5′-thioadenosine. The catabolism of of 5′-methylthioadenosine in Pseudomonas aeruginosa involves deamination to S-methyl-5′-thioinosine (EC 3.5.4.31, S-methyl-5′-thioadenosine deaminase) and phosphorolysis to hypoxanthine [1]. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Guan, R., Ho, M.C., Almo, S.C. and Schramm, V.L. Methylthioinosine phosphorylase from Pseudomonas aeruginosa. Structure and annotation of a novel enzyme in quorum sensing. Biochemistry 50 (2011) 1247–1254. [DOI] [PMID: 21197954] |
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| [EC 2.4.2.44 created 2011] |
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