ExplorEnz: EC 2.4.2.48

Your query returned 1 entry. Printable version

2.4.2.48

Accepted name:

tRNA-guanine¹⁵ transglycosylase

Reaction:

guanine¹⁵ in tRNA + 7-cyano-7-carbaguanine = 7-cyano-7-carbaguanine¹⁵ in tRNA + guanine

Glossary:

7-cyano-7-carbaguanine = preQ₀ = 7-cyano-7-deazaguanine
archaeosine = G* = 7-amidino-7-deazaguanosine

Other name(s):

tRNA transglycosylase (ambiguous); transfer ribonucleate glycosyltransferase (ambiguous); tRNA guanine¹⁵ transglycosidase; TGT (ambiguous); transfer ribonucleic acid guanine¹⁵ transglycosylase

Systematic name:

tRNA-guanine¹⁵:7-cyano-7-carbaguanine tRNA-D-ribosyltransferase

Comments:

Archaeal tRNAs contain the modified nucleoside archaeosine at position 15. This archaeal enzyme catalyses the exchange of guanine at position 15 of tRNA with the base preQ₀, which is ultimately modified to form the nucleoside archaeosine (cf. EC 2.6.1.97) [1].

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

1.	Bai, Y., Fox, D.T., Lacy, J.A., Van Lanen, S.G. and Iwata-Reuyl, D. Hypermodification of tRNA in thermophilic archaea. Cloning, overexpression, and characterization of tRNA-guanine transglycosylase from Methanococcus jannaschii. J. Biol. Chem. 275 (2000) 28731–28738. [DOI] [PMID: 10862614]

[EC 2.4.2.48 created 2012]