ExplorEnz: EC 2.5.1.128

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2.5.1.128

Accepted name:

N⁴-bis(aminopropyl)spermidine synthase

Reaction:

2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = 2 S-methyl-5′-thioadenosine + N⁴-bis(aminopropyl)spermidine (overall reaction)
(1a) S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = S-methyl-5′-thioadenosine + N⁴-aminopropylspermidine
(1b) S-adenosyl 3-(methylsulfanyl)propylamine + N⁴-aminopropylspermidine = S-methyl-5′-thioadenosine + N⁴-bis(aminopropyl)spermidine

Glossary:

spermidine = N-(3-aminopropyl)butane-1,4-diamine
N⁴-aminopropylspermidine = N,N′-bis(3-aminopropyl)butane-1,4-diamine
N⁴-bis(aminopropyl)spermidine = N,N,N′-tris(3-aminopropyl)butane-1,4-diamine

Systematic name:

S-adenosyl 3-(methylsulfanyl)propylamine:spermidine 3-aminopropyltransferase [N⁴-bis(aminopropyl)spermidine synthesizing]

Comments:

The enzyme, characterized from the thermophilic archaeon Thermococcus kodakarensis, synthesizes the branched-chain polyamine N⁴-bis(aminopropyl)spermidine, which is required for cell growth at high-temperature. When spermine is used as substrate, the enzyme forms N⁴-aminopropylspermine.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

Okada, K., Hidese, R., Fukuda, W., Niitsu, M., Takao, K., Horai, Y., Umezawa, N., Higuchi, T., Oshima, T., Yoshikawa, Y., Imanaka, T. and Fujiwara, S. Identification of a novel aminopropyltransferase involved in the synthesis of branched-chain polyamines in hyperthermophiles. J. Bacteriol. 196 (2014) 1866–1876. [DOI] [PMID: 24610711]

[EC 2.5.1.128 created 2014]