ExplorEnz: EC 2.5.1.139

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2.5.1.139

Accepted name:

umbelliferone 6-dimethylallyltransferase

Reaction:

prenyl diphosphate + umbelliferone = diphosphate + demethylsuberosin

For diagram of psoralen biosynthesis, click here

Glossary:

demethylsuberosin = 7-hydroxy-6-prenyl-1-benzopyran-2-one
osthenol = 7-hydroxy-8-prenyl-1-benzopyran-2-one

Other name(s):

PcPT; dimethylallyl-diphosphate:umbelliferone 6-dimethylallyltransferase

Systematic name:

prenyl-diphosphate:umbelliferone 6-prenyltransferase

Comments:

The enzyme from parsley (Petroselinum crispum) is specific for umbelliferone and prenyl diphosphate. A minor product is osthenol, which is produced by transfer of the prenyl group to C-8 of umbelliferone.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Hamerski, D., Schmitt, D. and Matern, U. Induction of two prenyltransferases for the accumulation of coumarin phytoalexins in elicitor-treated Ammi majus cell suspension cultures. Phytochemistry 29 (1990) 1131–1135. [DOI] [PMID: 1366425]
2.	Karamat, F., Olry, A., Munakata, R., Koeduka, T., Sugiyama, A., Paris, C., Hehn, A., Bourgaud, F. and Yazaki, K. A coumarin-specific prenyltransferase catalyzes the crucial biosynthetic reaction for furanocoumarin formation in parsley. Plant J. 77 (2014) 627–638. [DOI] [PMID: 24354545]

[EC 2.5.1.139 created 2017]